Welcome to the Cosa Group
Understanding cellular signaling and cellular function in disease and health and developing faster diagnostics for disease detection, to name but a few of the emerging frontiers in natural sciences, demand that we improve our ability to visualize and quantify fluctuations in chemical composition, chemical interactions and macromolecular structure in the cell.
Our research activities involve three main aspects of Chemical Imaging with an emphasis in fluorescence :
Chemical Synthesis of Fluorescent Probes
The design and chemical synthesis of Reactive Oxygen Species-sensitive fluorescent probes, and their subsequent use in live-cell studies. Our probes will shed light on the role of ROS in cellular signal transduction or in pathologies such as neurodegenerative diseases.
The fabrication of nanocomposite materials for biophotonic applications; novel biomaterials with unique optical properties intended for protein-lipid membrane interaction studies and for developing novel high throughput sensing platforms.
Single Molecule Spectroscopy
The utilization and development of state-of-art nanotools, specifically single molecule fluorescence techniques, to unravel complex mechanistic interactions and understand inhibitor mechanisms on polymerase activities. We seek to provide a “molecular movie” with nanometer spatial resolution and microsecond time resolution, enabling, the characterization of an enzyme dynamic behavior at the single molecule level.